You know I love going to Disneyland and Knott's Berry Farm. Although you might consider me "local" I still have to drive 80 miles to get there. Without traffic that is around 1 hour and 30 minutes, but with traffic it can be 3 to 4 hours.
Most times we are going to Anaheim, I try to book a hotel so we can sleep in a little and do not have to get up so early and be stuck in traffic. There are several hotels in the area, but one of our favorites is Howard Johnson in Anaheim. It is only a 8 minute walk to the entrance of the park and has great rooms. (they have one building already renewed and another one is being renewed right now)